What does 5-MeO-DMT look like and where does it come from?
DMT Pupe. As a defence mechanism, the Colorado River Toad secretes a white milky substance called ‘Bufotoxin’ from areas behind its eyes called ‘parotoid glands’.
When dried this contains up to 30% 5-MeO-DMT by mass, alongside other substances such as Bufotenine, DMT, NMT, DET, N-Methylserotonin and Bufogenin. DMT Vape Pen
There is no evidence of a difference between synthetic 5-MeO-DMT and that secreted by the Bufo Alvarius toad, meanwhile there are concerns regarding the environmental impact that Bufotoxin collection may be having on local toad populations at the United States and Mexico border.
The 5-MeO-DMT content of natural toad secretions can vary greatly between samples, which makes accurate dosing more difficult.
This can be dangerous because 5-MeO-DMT is very powerful, even at low dosages, and the effects are highly dose-dependant, following a steep dose-response curve. DMT Pupe
5-MeO-DMT is most commonly consumed in the form of a synthetic white, crystalline powder. Typical doses of 5-MeO-DMT are very small, typically 5mg, so care should always be taken by using accurate scales and researching the appropriate doses.
5-MeO-DMT in this form is typically either vapourised in a pipe and inhaled or less commonly insufflated (snorted).
How does 5-MeO-DMT work as a drug in the body and brain?
After being vaporised and inhaled 5-MeO-DMT quickly passes the blood-brain barrier. It shares a similar chemical structure with the neurotransmitter serotonin, which means it can fit into some of the serotonin receptors in the brain where it acts as an agonist, meaning it stimulates the receptor – especially the 5-HT2A subtype of the serotonin receptor. DMT Pupe
Stimulation of these Serotonin receptors leads to the psychedelic state e.g hallucinations, and can affect mood and body temperature.
5-MeO-DMT is a relatively short-acting psychedelic drug and the ‘trip’ usually lasts less than 30 minutes when smoked, and up to 45 minutes when insufflated.
When vapourised and inhaled the effects begin almost instantaneously, which means it is very important to be in a safe and comfortable environment to avoid accidents
Users often report overwhelmingly intense experiences which can sometimes be difficult to remember. Accounts of mystical union, feelings of non-duality and experiences of a transpersonal nature are not uncommon.
Often uncomfortable bodily sensations such as a rapid heart rate, nausea and pressure in the chest can be present.